Journal article
Human papillomavirus seroprevalence and association with anal HPV infection and squamous intraepithelial lesions in Australian gay and bisexual men
IM Poynten, T Waterboer, F Jin, DJ Templeton, RJ Hillman, C Law, A Cornall, S Tabrizi, JM Roberts, SM Garland, CK Fairley, AE Grulich
Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2018
Abstract
Background: Gay and bisexual men (GBM) are at disproportionately high risk of anal cancer. The precursor lesions, high-grade squamous intraepithelial lesions (HSIL), are very common and it is evident that not all HSIL progresses to cancer. The serologic response to anal human papillomavirus (HPV) in GBM has not been well characterized. Methods: The Study of the Prevention of Anal Cancer is an ongoing cohort study of GBM ages 35 years and older. At six visits over three years, anal samples are collected for cytology, HPV DNA testing, and histology. Baseline serum was tested for HPV L1, E6, and E7 antibodies for 10 HPV types. Seroprevalence and associated predictors were analyzed. Results: A t..
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Funding Acknowledgements
This research is supported by a National Health and Medical Research Council Program New Investigator Grant (to I.M. Poynten). The SPANC study is funded by a National Health and Medical Research Council Program Grant (Sexually Transmitted Infections: Causes, Consequences and Interventions Grant # 568971; to A.E. Grulich and C.K. Fairley) and a Cancer Council New South Wales Strategic Research Partnership Program Grant (Preventing Morbidity and Mortality from Anal Cancer Grant # 13-11; I.M. Poynten, F. Jin, R.J. Hillman, D.J. Templeton, S. Tabrizi, S.M. Garland, AF, C.K. Fairley). Cytologic testing materials were provided by Hologic (Australia) Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales and funded by the Australian Government of Health and Ageing.